2,4-Pentadienoic acid, methyl ester → HCID 20435924, compound

HRID 1154047Notes

Reaction equation

HRID 1154047 reaction equation
[CH2:1]([C:3]1([CH2:10][CH2:11][O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][O:14]2)[C:7](=[O:8])[NH:6][NH:5][C:4]1=[O:9])[CH3:2].[C:19]([O:25][CH3:26])(=[O:24])[CH:20]=[CH:21][CH:22]=[CH2:23]>>[CH2:1]([C:3]1([CH2:10][CH2:11][O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][O:14]2)[C:4](=[O:9])[N:5]2[CH2:23][CH:22]=[CH:21][CH:20]([C:19]([O:25][CH3:26])=[O:24])[N:6]2[C:7]1=[O:8])[CH3:2]

Participants

3

Reactant 2

HCID 736882,4-Pentadienoic acid, methyl esterHCID 20435966HCID 20435966, compound

Product 1

HCID 20435924HCID 20435924, compoundYield 59%

Procedure

In a manner analogous to that described in Example 7(B) (b), from 7.75 g of 4-ethyl-4-[2-(tetrahydro-2-pyranyloxy)ethyl]pyrazolidine-3,5-dione and 3.7 g of methyl penta-2,4-dienoate there were obtained 6.49 g (59%) of methyl 2-ethyl-2,3,5,8-tetrahydro-1,3-dioxo-2-[2-(tetrahydro-2-pyranyloxy)ethyl]-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in the form of a white solid having a melting point of 96°-97° C. (from diethyl ether).

Sources & evidence

ORD record
ord-1d7324a952bb47528cb90060cab9e98f
Source dataset
uspto-grants-1984_12
Patent number
US04487929

Reaction notes

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