4-Fluorobenzoic Acid → 4-Fluorobenzoyl chloride

HRID 1154081Notes

Reaction equation

HRID 1154081 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][CH:3]=1.S(Cl)([Cl:13])=O>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:13])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 99734-Fluorobenzoic AcidHCID 24386Thionyl Chloride

Product 1

HCID 678794-Fluorobenzoyl chloride

Procedure

On the other hand, 4-fluorobenzoic acid (0.01 mol) (1.4 g) was reacted with thionyl chloride (10 ml) at 60° C. for 30 minutes and then at 80° C. for 2 hours to obtain a uniform solution, which was then allowed to stand for one hour, followed by distilling off excess thionyl chloride to obtain 4-fluorobenzoyl chloride as residue.

Workup

  1. customat 80° C. for 2 hours to obtain a uniform solution, which
  2. distillationby distilling off excess thionyl chloride

Sources & evidence

ORD record
ord-684f91a5587a4777b9aec1cd1f4c9927
Source dataset
uspto-grants-1984_12
Patent number
US04487954

Reaction notes

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