4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → HCID 178419046, compound

HRID 11541Notes

Reaction equation

HRID 11541 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:18]=1[C:19](=[CH:27]O)[C:20](=[O:26])[NH:21]2>>[F:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:18]=1[C:19](=[CH:27][NH:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:14][CH:13]=1)[C:20](=[O:26])[NH:21]2

Participants

3

Reactant 2

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 178418878HCID 178418878, compound

Product 1

HCID 178419046HCID 178419046, compoundYield 77.1%

Procedure

In a manner similar to that described in Example 231, 4-(2-pyrrolidin-1-yl-ethoxy)-phenylamine (690 mg, 1.2 equiv.) and 4-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 2.79 mmol, 1 equiv.) to give the named compound as a yellow solid (790 mg, 77.0%).

Sources & evidence

ORD record
ord-ce4b58c430e84771ac46e534aefbc03e
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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