Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-hydroxy-1,2,3-benzotriazin-4(3H)-one | HCID 73026 | — |
| Reactant | HCID 13178797 | HCID 13178797 | — |
| Reactant | HCID 178451199 | HCID 178451199 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 178453396 | HCID 178453396 | — |
Reaction Steps
0.26 ml of N-ethylmorpholine and 440 mg of DCC are added at 0° C. to a solution of 1.95 g (2 mmoles) of Z-Lys(Boc)-Lys(Boc)-Tyr(But)-Phe-OH, 606 mg (2 mmoles) of H-Arg-OBut.HCl and 326 mg (2 mmoles) of HOObt in 5 ml of dimethylacetamide. The mixture is first stirred for 2 hours at 0° C. and is left to stand overnight at room temperature. On the following day the precipitate is filtered off and the filtrate is concentrated. Yield 2.5 g. The substance is purified by being recrystallized twice from ethyl acetate. Yield 1.7 g, melting point 134°-137°, [α]D26 =-26.4° (c=1, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04487764 |
|---|
| Source dataset | uspto-grants-1984_12 |
|---|
| ORD ID | ord-721a6dd5d4b24911a71f5a1d3d9c85d5 |
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| Source note | uspto-grants-1984_12 |
|---|
