HCID 178453396, compound → HCID 178476579, compound

Participants

Reaction Steps

1.6 g of Z-Lys(Boc)-Lys(Boc)-Tyr(But)-Phe-Arg-OBut are dissolved in 15 ml of 90% strength trifluoroacetic acid. The solution is left to stand at room temperature for 1 hour and is concentrated. The residue is triturated with ether and is suction-drained. The residue is then dissolved in water and chromatographed over a weakly basic ion exchanger (acetate form). The eluate is concentrated and chromatographed in 90% strength methanol over a crosslinked, hydroxypropylated dextran gel. Yield 920 mg, [α]D24 =-29.7° (c=1, methanol).

Provenance & Evidence