Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-(Benzyloxycarbonyl)-D-phenylalanine | HCID 675678 | — |
| Reactant | HCID 131714059 | HCID 131714059 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13178807 | HCID 13178807 | — |
Reaction Steps
1.28 ml (10 mmoles) of N-ethylmorpholine and 2.26 g (11 mmoles) of DCC are added at 0° C. to a solution of 3.46 g (10 mmoles) of H-Trp-Pro-OBut.HCl. 2.29 g (10 mmoles) of Z-D-Phe-OH and 1.35 g (10 mmoles) of HOBt in 25 ml of dimethylformamide. The mixture is stirred for 2 hours at 0° C. and left to stand overnight at room temperature. The precipitate is filtered and the filtrate is concentrated. The residue is worked up analogously to Example 1 a. The residue crystallizes from ether. Yield 3.91 g (61%), melting point 186°, [α]D23 =-53.6° (c=1, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04487764 |
|---|
| Source dataset | uspto-grants-1984_12 |
|---|
| ORD ID | ord-8b0894fd8b2a43a49dc6d61d882724cc |
|---|
| Source note | uspto-grants-1984_12 |
|---|
