HCID 178453397, compound → HCID 178512883, compound

Participants

Reaction Steps

1.55 g of Z-D-Lys(Boc)-Arg-D-Phe-Trp-Pro-OBut are dissolved in 14.5 ml of 90 percent strength trifluoroacetic acid and 1.5 ml of ethyl mercaptan. The solution is left to stand for 1 hour at room temperature and is concentrated. The residue is dissolved in water and chromatographed over a weakly basic ion exchanger (acetate form). The eluate is freeze-dried. Yield 883 mg. The peptide is purified by being chromatographed in 90 percent strength methanol over a crosslinked, hydroxypropylated dextran gel. Yield 570 mg, [α]D22 =-24.6° (c=1, methanol).

Provenance & Evidence