Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → 5-fluoro-3-[[4-(2-pyrrolidin-1-ylethoxy)anilino]methylidene]-1H-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2-(Pyrrolidin-1-yl)ethoxy)aniline | HCID 6493749 | — |
| 반응물 | HCID 178418836 | HCID 178418836 | — |
| 생성물 | 5-fluoro-3-[[4-(2-pyrrolidin-1-ylethoxy)anilino]methylidene]-1H-indol-2-one | HCID 178418981 | 69% |
반응 단계
In a manner similar to that described in Example 231, 4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine (690 mg, 1.2 equiv.) and 5-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 2.79 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (705 mg, 69%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098236B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-7c64fb7189b2415199b6b89369a8a6fb |
| 출처 메모 | uspto-grants-2006_08 |