Tetrabutylammonium Fluoride → HCID 20434936, compound

Participants

Reaction Steps

A mixture of 3-methyl-6H-1,2,6-thiadiazine-1,1-dioxide (0.584 g) and 1-(6,7-dimethoxyquinazolin-4-yl)-4-iodomethylpiperidine (0.826 g) were heated under reflux with tetrabutylammonium fluoride (4 ml; 1.0M in tetrahydrofuran [T.H.F.]) for 24 hours. The solvent was then removed in vacuo and the residue was chromatographed on silica (Merck 60.9385) eluting with chloroform to give a foam. Crystallisation from ethyl acetate gave 1-(6,7-dimethoxyquinazolin-4-yl)-4-(1,1-dioxo-5-methyl-1,2,6-thiadiazin-2-yl)methylpiperidine as white needles, m.p. 203°-207°, (0.35 g).

Provenance & Evidence