Hydrochloric Acid → HCID 13371118, compound

Participants

Reaction Steps

A solution of 5.6 g. of 4-[bis[3-(p-chlorophenyl)propyl]amino]benzoic acid, ethyl ester and 3 g. of 85% potassium hydroxide in 50 ml. of ethanol is stirred at 75° C. for 4 hours, cooled, diluted with 100 ml. of water, and adjusted to pH 6.0 with 37% hydrochloric acid. The solution is extracted with two 150 ml. portions of ether. The ether extracts are combined, washed with 100 ml. of water, then 100 ml. of brine, dried over magnesium sulfate, and evaporated to an orange solid. This solid is recrystallized twice from 50 ml. of acetonitrile, giving 1.39 g. of the desired product, m.p. 128°-131° C.

Provenance & Evidence