Water → HCID 12683867, compound

HRID 1154372Notes

Reaction equation

HRID 1154372 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[NH:16][CH:15]=[N:14][C:13]=3[C:12](=[O:18])[N:11]3[CH2:19][CH2:20][N:21]=[C:10]23)=[CH:4][CH:3]=1.O.[OH-].[Na+].[CH3:25]I>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[N:16]=[CH:15][N:14]([CH3:25])[C:13]=3[C:12](=[O:18])[N:11]3[CH2:19][CH2:20][N:21]=[C:10]23)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178515261HCID 178515261, compound

Product 1

HCID 12683867HCID 12683867, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-[(4-Chlorophenyl)methyl]-6,7-dihydro-3H-imidazo-[1,2-a]purin-9(4H)-one (Procedure 3), 6.02 g. (0.02 mole), is dissolved with warming in a mixture of 100 ml. of water and 15 ml. of ethanol containing 1.0 g. (0.25 mole) of sodium hydroxide. Approximately 3 ml. (approximately a molar equivalent) of methyl iodide was added and the mixture was stirred for about 48 hrs. at room temperature. The precipitated solid was collected, air dried, and recrystallized from isopropanol, m.p. 182.5°-184.5°.

Workup

  1. dissolution(0.02 mole), is dissolved
  2. temperaturewith warming in a mixture of 100 ml
  3. customat room temperature
  4. customThe precipitated solid was collected
  5. customair dried
  6. customrecrystallized from isopropanol, m.p. 182.5°-184.5°

Sources & evidence

ORD record
ord-fb84254ee07747d09125a7d8159f25f3
Source dataset
uspto-grants-1984_12
Patent number
US04489078

Reaction notes

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