HCID 86739794, compound → HCID 20217719, compound

HRID 1154383Notes

Reaction equation

HRID 1154383 reaction equation
[I-].ClC1C=CC(C[N:10]2[C:18]3[N:17]=[CH:16][NH+:15]([CH3:19])[C:14]=3[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][N:23]([CH3:24])[CH:11]23)=CC=1>[Pd].CCO>[CH3:19][N:15]1[C:14]2[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][N:23]([CH3:24])[C:11]3=[N:10][C:18]=2[N:17]=[CH:16]1

Participants

4

Reactant 1

HCID 86739794HCID 86739794, compound

Product 1

HCID 20217719HCID 20217719, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the quaternary salt of Procedure 94 and 10% palladium on carbon in abs. EtOH is subjected to hydrogenolysis at a pressure of about 50 psig. The spent catalyst is removed by filtration, the filtrate concentrated in vacuo, and the residue dissolved in water. Treatment with concentrated NH4OH liberates the free base which is collected and dried.

Workup

  1. customThe spent catalyst is removed by filtration
  2. concentrationthe filtrate concentrated in vacuo
  3. dissolutionthe residue dissolved in water
  4. customis collected
  5. customdried

Sources & evidence

ORD record
ord-32050ae9a4464a279ae3b77b40c4f37d
Source dataset
uspto-grants-1984_12
Patent number
US04489078

Reaction notes

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