4-[3-(1-Piperidinyl)propoxy]aniline → 6-(3-methoxyphenyl)-3-[[4-(3-piperidin-1-ylpropoxy)anilino]methylidene]-1H-indol-2-one

Participants

Reaction Steps

The named compound is prepared by refluxing 0.020 gms E & Z 3-hydroxymethylene-6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one (see example 268) with 0.0375 gms 4-(3-piperidin-1-yl-propoxy)-phenylamine (used in the preparation of Example 218) in tetrahydrofuran (0.33 mL) for 36 h. Following cooling to room temperature, solvent evaporation in vacuo, trituration with isopropanol and filtration the reaction yields the named compound as a solid in the amount of 16.8 mg.

Provenance & Evidence