HRID1154420

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12803645

(2S)-(4-Fluoro-3-phenoxyphenyl)(hydroxy)acetonitrile

C14H10FNO2

$结构：CC(C)(C)OC(=O)/C(F)=C\[C@H]1[C@@H](C(=O)O)C1(C)C$

HCID13372597

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)/C(F)=C\[C@H]1[C@@H](C(=O)O[C@H](C#N)c2ccc(F)c(Oc3ccccc3)c2)C1(C)C$

HCID13372614

未命名化合物

PROCEDURE

实验过程

Using the procedure of Step B of Example 43, (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropane carboxylic acid and (S)α-cyano-3-phenoxy-4-fluoro-benzyl alcohol were reacted to obtain (S)α-cyano-3-phenoxy-4-fluoro-benzyl (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropanecarboxylate melting at 122° C. and having a specific rotation of [α]D20 =+61°±2.5° (c=0.35% in chloroform).

WORKUP

后处理

customwere reacted