2,4-Imidazolidinedione, 3-(hydroxymethyl)-1-(2-propynyl)- → HCID 86739832, compound

HRID 1154426Notes

Reaction equation

HRID 1154426 reaction equation
[CH3:1][C:2]1([CH3:15])[C@@H:4](/[CH:5]=[C:6](/[F:11])\[C:7](=[O:10])[O:8][CH3:9])[C@H:3]1[C:12]([OH:14])=[O:13].[CH2:16]([N:19]1[CH2:23][C:22](=[O:24])[N:21]([CH2:25]O)[C:20]1=[O:27])[C:17]#[CH:18]>C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:15])[C@@H:4](/[CH:5]=[C:6](/[F:11])\[C:7](=[O:10])[O:8][CH3:9])[C@H:3]1[C:12]([O:14][CH2:25][N:21]1[C:22](=[O:24])[CH2:23][N:19]([CH2:16][C:17]#[CH:18])[C:20]1=[O:27])=[O:13]

Participants

4

Reactant 2

HCID 117895972,4-Imidazolidinedione, 3-(hydroxymethyl)-1-(2-propynyl)-HCID 13649738HCID 13649738, compound

Product 1

HCID 86739832HCID 86739832, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using the procedure of Step B of Example 43, (1R,cis,E) 2,2-dimethyl-3-(2-fluoro-3-oxo-3-methoxy-1-propenyl)-cyclopropane carboxylic acid and [3-(2-propyn-1-yl)-2,5-dioxo-1-imidazolidinyl]-methanol were reacted to obtain [3-(2-propyn-1-yl)-2,5-dioxo-1-imidazolidinyl]-methyl (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-methoxy-1-propenyl]-cyclopropanecarboxylate with a specific rotation of [α]D20 =+3.5°±2° (c=0.5% in chloroform).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a52654c7bb284fe1a5dc0ade9f7830d7
Source dataset
uspto-grants-1984_12
Patent number
US04489093

Reaction notes

Loading…