反应详情

15 g (43.4 mmol) of ethyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate and 1.85 g (46.3 mmol) of sodium hydroxide are treated with 60 ml of ethanol and 10 ml of water, the mixture is then heated to boiling under reflux for 45 minutes, the ethanol is subsequently distilled off in vacuo, the mixture remaining is treated with 46.5 ml of 1N hydrochloric acid and left to stand in an ice-bath for 2 hours. The precipitated material is filtered off under suction, washed with water and dried up to constant weight. There is obtained (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid having a decomposition point of 265°.

1. temperaturethe mixture is then heated
2. temperatureunder reflux for 45 minutes
3. distillationthe ethanol is subsequently distilled off in vacuo
4. additionthe mixture remaining is treated with 46.5 ml of 1N hydrochloric acid
5. waitleft
6. filtrationThe precipitated material is filtered off under suction
7. washwashed with water
8. customdried up to constant weight