Cyclopentanol → HCID 20434809, compound

Participants

Reaction Steps

3.19 g (10 mmol) of ethyl 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, 70 mg of powdered potassium cyanide and 10 ml of cyclopentanol are stirred at 120° overnight, subsequently evaporated and the residue is chromatographed on silica gel while eluting with ethyl acetate. By recrystallization from ethyl acetate there is obtained cyclopentyl 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate of melting point 162°-163°.

Provenance & Evidence