Potassium Cyanide → HCID 54320306, compound

Participants

Reaction Steps

A mixture of 3.45 g (10 mmol) of ethyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate, 100 mg (1.5 mmol) of potassium cyanide and 20 ml of 2-methoxybenzyl alcohol is stirred at 110° for 36 hours, the resulting ethanol being removed in vacuo from time to time. The solvent is subsequently removed by distillation in a high vacuum and the residue is chromatographed on silica gel while eluting with ethyl acetate. By recrystallization from ethyl acetate/n-hexane there is obtained o-methoxybenzyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate of melting point 178°-179°.

Provenance & Evidence