Water → HCID 2826591, compound

Participants

Reaction Steps

A solution of 2H-1,4-benzothiazine-3(4H-one (2 g) and 4-chlorobenzaldehyde (2.6 g) in dimethylformamide (15 ml) was treated with sodium methylate (0.98 g). The temperature of the mixture rose spontaneously. After cooling to room temperature, the reaction mixture was stirred and heated at 110° C. with a continuous removal of a low boiling substance for 3 hours. The reaction mixture was cooled to 30° C., and poured onto 100 ml of iced water. The resulted yellow solid was filtered and recrystallized from a mixture of dimethylformamide and isopropyl alcohol. 2-(4-Chlorophenylmethylidene)-2H-1,4-benzothiazine-3(4H)-one (3.3 g) was obtained as yellow crystals. m.p. 245-248° C.

Provenance & Evidence