HRID1154547

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID559542

2-Fluoro-1H-imidazole

C3H3FN2

结构：CC1(C)S[C@@H]2C(N)C(=O)N2C1C(=O)OCc1ccc([N+](=O)[O-])cc1.Cc1ccc(S(=O)(=O)O)cc1

HCID86739845

未命名化合物

PRODUCTS

生成物

结构：CC1(C)S[C@@H]2C(Nc3ncc[nH]3)C(=O)N2C1C(=O)OCc1ccc([N+](=O)[O-])cc1.Cc1ccc(S(=O)(=O)O)cc1

HCID86739843

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A mixture of p-nitrobenzyl 6-amino-2,2-dimethylpenam-3-carboxylate toluene-p-sulphonate (523 mg.) and 2-fluoroimidazole (100 mg.) in acetonitrile (2 ml.) was stirred at 50° for 3 hours. The resulting solution was evaporated to dryness and the residue obtained was triturated with ether to give p-nitrobenzyl 2,2-dimethyl-6-(imidazol-2-yl)aminopenam-3-carboxylate toluene-p-sulphonate as a 50% pure solid (572 mg.) which was used without further purification.

WORKUP

后处理

customThe resulting solution was evaporated to dryness
customthe residue obtained
customwas triturated with ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-30acf8c1cf4546e38653bba4094b7330
来源数据集: uspto-grants-1984_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04490382
来源说明: uspto-grants-1984_12

反应 SMILES

[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[NH2:12][CH:13]1[C:34](=[O:35])[N:15]2[CH:16]([C:21]([O:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=3)=[O:22])[C:17]([CH3:20])([CH3:19])[S:18][C@H:14]12.F[C:37]1[NH:38][CH:39]=[CH:40][N:41]=1>C(#N)C>[C:1]1([CH3:11])[CH:2]=[CH:3][C:4]([S:7]([OH:10])(=[O:8])=[O:9])=[CH:5][CH:6]=1.[CH3:19][C:17]1([CH3:20])[CH:16]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=2)=[O:22])[N:15]2[C:34](=[O:35])[CH:13]([NH:12][C:37]3[NH:38][CH:39]=[CH:40][N:41]=3)[C@H:14]2[S:18]1