HCID 178430889, compound → HCID 178430890, compound

Participants

Reaction Steps

A mixture of p-nitrobenzyl 2,2-dimethyl-6-(4-methylimidazol-2-yl)aminopenam-3-carboxylate toluene-p-sulphonate (200 mg.) and 10% w/w palladium-on-carbon in ethanol (12 ml.) and methylene chloride (3 ml.) was shaken under hydrogen at atmospheric pressure for 3.5 hours. The mixture was filtered, the filtrate evaporated to dryness and the residual gum triturated with ether to give 2,2-dimethyl-6-(4-methylimidazol-2-yl)aminopenam-3-carboxylic acid toluene-p-sulphonate as a yellow powder (118 mg.) having the following n.m.r. in d6DMSO+CD3COOD: 1.5 (s, 3H); 1.6 (s, 3H); 2.11 (s, 3H); 2.3 (s, 3H); 4.35 (s, 1H); 5.40 (d, 1H); 5.62 (d, 1H); 6.72 (s, 1H); 7.1 (d, 2H); 7.5 (d, 2H); 8.76 (s, 1H). The sample was approximately 50% pure.

Provenance & Evidence