反应详情

A mixture of 3,4-dimethoxyphenylisocyanate (26.0 g, 145 mM) and propionamide (10.61 g, 145 mM) is heated at 160°-165° C. for 11/2 hours. A homogeneous pale yellow solution forms which after 15 minutes solidifies. The heating is discontinued and the flask is allowed to cool slowly. The mixture is triturated with acetone and this resulting white solid is filtered and dried. Yield: 32.45 g, mp 193°-197° C.

1. temperatureis heated at 160°-165° C. for 11/2 hours
2. temperatureto cool slowly
3. customThe mixture is triturated with acetone
4. filtrationthis resulting white solid is filtered
5. customdried