Nitric Acid → HCID 178486919, compound

HRID 1154556Notes

Reaction equation

HRID 1154556 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[N:7]=[C:6]2[CH3:16].[N+:17]([O-])([OH:19])=[O:18].OS(O)(=O)=O>>[CH3:1][O:2][C:3]1[C:4]([N+:17]([O-:19])=[O:18])=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[N:7]=[C:6]2[CH3:16]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178486917HCID 178486917, compound

Product 1

HCID 178486919HCID 178486919, compound

Procedure

One equivalent of 6,7-dimethoxy-4-methyl-2(1H)quinazolinone is added during 3/4 hr. to a mixture (5:1) of 6 equivalents of concentrated nitric acid (70%) and concentrated H2SO4 at 0°±3° C. After one hour at the same temperature the solution is poured onto crushed ice (1000 ml). The crude product is collected by filtration, digested with boiling alcohol and the suspension is filtered. Crystallization from ethyl alcohol affords 6,7-dimethoxy-5-nitro-4-methyl-2(1H)quinazolinone.

Workup

  1. customat 0°±3° C
  2. additionAfter one hour at the same temperature the solution is poured
  3. filtrationThe crude product is collected by filtration
  4. filtrationthe suspension is filtered
  5. customCrystallization from ethyl alcohol

Sources & evidence

ORD record
ord-e750a613d2fa4741a62cf210612e9835
Source dataset
uspto-grants-1984_12
Patent number
US04490374

Reaction notes

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