HCID 13365018, compound → HCID 178488104, compound

HRID 1154566Notes

Reaction equation

HRID 1154566 reaction equation
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]([C:16](F)(F)F)[NH:6][C:7](=[O:15])[NH:8]2.COC1C(OC)=CC=C2C=1C(C(C)C)NC(=O)N2.C1(C2C3C(=CC=C(OC)C=3OC)NC(=O)N2)CCCCC1.COC1C(OC)=CC=C2C=1C(C)NC(=O)N2.COC1C(OC)=CC=C2C=1C(C(F)(F)F)=NC(=O)N2.COC1C(OC)=CC=C2C=1C(C(C)C)=NC(=O)N2.C1(C2C3C(=CC=C(OC)C=3OC)NC(=O)N=2)CCCCC1>>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([CH3:16])=[N:6][C:7](=[O:15])[NH:8]2

Participants

8

Reactant 7

HCID 13365018HCID 13365018, compoundHCID 20224569HCID 20224569, compoundHCID 20224570HCID 20224570, compoundHCID 20224574HCID 20224574, compoundHCID 178488103HCID 178488103, compoundHCID 178488106HCID 178488106, compoundHCID 178488107HCID 178488107, compound

Product 1

HCID 178488104HCID 178488104, compound

Procedure

When in the above procedure 3,4-dihydro-5,6-dimethoxy-4-trifluoromethyl-2(1H)quinazolinone, 3,4-dihydro-5,6-dimethoxy-4-isopropyl-2(1H)quinazolinone and 3,4-dihydro-4-cyclohexyl-5,6-dimethoxy-2(1H)quinazolinone are employed in place of 3,4-dihydro-5,6-dimethoxy-4-methyl-2(1H)quinazolinone the corresponding 5,6-dimethoxy-4-trifluoromethyl-2(1H)quinazolinone, 5,6-dimethoxy-4-isopropyl-2(1H)quinazolinone and 4-cyclohexyl-5,6-dimethoxy-2(1H)quinazolinone are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-eafbf840bfcf4fac9a9ec02e1c7876e2
Source dataset
uspto-grants-1984_12
Patent number
US04490374

Reaction notes

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