Ammonia → HCID 178487562, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-acetyl-3(3-methoxyphenyl)urea (32.5 g, 0.156 m) and polyphosphoric acid (912.5 g) is heated at 120°-130° C. for 2 hours. After cooling to 50° C. the melt is poured on ice-water (2 liters), and the solution is made weakly basic with ammonia and left standing overnight. The brownish-red precipitate which forms is filtered off, washed with cold water followed by hot acetone, and crystallized from ethanol (after treatment with charcoal) to give the product as a pale yellow solid; yield 11.5 g (39.1%); mp 251°-254° C.

Provenance & Evidence