HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Dimethylamino)ethanol → N,N1-Dimethyl-S-(2-dimethylaminoethyl)isothiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| Reactant | 1,1-Dimethyl-2-thiourea | HCID 3034192 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | N,N1-Dimethyl-S-(2-dimethylaminoethyl)isothiourea | HCID 86736996 | 128% |
Reaction Steps
A mixture of 2-dimethylaminoethanol (2.23 g), N,N1 -dimethylthiourea (2.6 g) and aqueous hydrobromic acid (48%, 20 ml) was boiled under reflux for 50 hours and evaporated to dryness. The residue was recrystallized from a mixture of methanol and ethanol to give the dihydrobromide of the title compound (5.6 g) m.p. 198°-199°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04490387 |
| Source dataset | uspto-grants-1984_12 |
| ORD ID | ord-64f7c8af24e0420ca904ad06a82650fe |
| Source note | uspto-grants-1984_12 |