HCID 131712896, compound → HCID 86738677, compound

HRID 1154570Notes

Reaction equation

HRID 1154570 reaction equation
O.O.O.[Na].[CH3:5][C:6]1([CH3:21])[CH:15]=[C:14]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1>O>[CH3:5][C:6]1([CH3:21])[CH:15]=[C:14]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1

Participants

3

Reactant 1

HCID 131712896HCID 131712896, compound

Product 1

HCID 86738677HCID 86738677, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6.5 g. of (2,2-dimethyl-1,2-dihydroquinoline-4-yl)-methylsulfonic acid sodium salt trihydrate in 20 ml. of water are passed through a chromatographic column filld with 120 g of DOWEX 50 WX 10 cation exchanging resin. The column is washed with distilled water and the eluted solution is evaporated. The precipitated substance is filtered, washed with ethyl acetate and dried at room temperature, 4.5 g. (88%) of (2,2-dimethyl-1,2-dihydroquinoline-4-yl)-methylsulfonic acid are obtained, melting at 256° to 260° C.

Workup

  1. washThe column is washed with distilled water
  2. customthe eluted solution is evaporated
  3. filtrationThe precipitated substance is filtered
  4. washwashed with ethyl acetate
  5. customdried at room temperature

Sources & evidence

ORD record
ord-9c26ba314cd149ea8c10e07318994113
Source dataset
uspto-grants-1984_12
Patent number
US04490394

Reaction notes

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