Pyridine → HCID 178505334, compound

Participants

Reaction Steps

To a solution of 2.1 g of 6-quanidinocaproic acid in 50 ml of dried pyridine, was added 3.1 g of DCC. After 30 minutes of stirring, 2.6 g of 4-(β-amidinoethenyl)phenol methanesulfonate was added and the mixture was stirred overnight. The insolubles were separated by filtration, suspended in DMF, and removed by filtration. Ethyl ether was added to the combined filtrate to precipitate an oily substance. The oily substance was separated, added to a saturated aqueous sodium bicarbonate solution and stirred to precipitate yellow crystals. The crystals were suspended in ethanol and admixed with methanesulfonic acid to form a clear solution. Ethyl ether was added to the solution and the precipitated crystals were collected by filtration and recrystallized from ethanol to obtain 1.8 g of 4-(β-amidinoethenyl)phenyl 6-guanidinocaproate dimethanesulfonate.

Provenance & Evidence