Dicyclohexylcarbodiimide → HCID 178512132, compound

Participants

Reaction Steps

To a solution of 5.0 g of trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid in 50 ml of dried pyridine, while being cooled in ice, was added 4.2 g of DCC. After 30 minutes of stirring, to the mixture was added 4.4 g of 4-(β-amidinoethenyl)phenol methanesulfonate. The mixture was stirred overnight at room temperature. The DCU precipitated from the reaction mixture was separated by filtration and washed with pyridine. Ethyl ether was added to the combined filtrate to precipitate a white substance which was collected by filtration, washed with ethyl ether, and recrystallized from ethanol to yield 5.7 g of colorless needle crystals of 4-(β-amidinoethenyl)pnenyl trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate methanesulfonate.

Provenance & Evidence