Sulfuric Acid → HCID 135626237, compound

HRID 1154602Notes

Reaction equation

HRID 1154602 reaction equation
C(O)(=O)C.[CH2:5]([N:12]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:13](=[O:32])[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[N:24]=[C:23]1[NH:28][C:29](=[O:31])[CH2:30][N:22]1[CH2:21]2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[S:40](=[O:44])(=[O:43])([OH:42])[OH:41]>O>[S:40]([OH:44])([OH:43])(=[O:42])=[O:41].[CH2:33]([N:12]([CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[C:13](=[O:32])[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[N:24]=[C:23]1[NH:28][C:29](=[O:31])[CH2:30][N:22]1[CH2:21]2)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 135626480HCID 135626480, compound

Product 1

HCID 135626237HCID 135626237, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N-dibenzyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramide acetate (1.0 g) is dissolved in 50 ml water containing a stoichiometric equivalent of sulfuric acid, and the solution evaporated to dryness. The product is suspended in ethanol and filtered, air dried and recrystallized from methanol/acetone to yield N,N-dibenzyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramide sulfate.

Workup

  1. customthe solution evaporated to dryness
  2. filtrationfiltered
  3. customair dried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-4c243b52f78547a5af9f80491d307a8f
Source dataset
uspto-grants-1984_12
Patent number
US04490371

Reaction notes

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