(+-)-3,4-Dimethoxyamphetamine → alpha-(alpha-Methyl-3,4-dimethoxyphenylethylimino)-2-n-butoxyacetophenone

HRID 1154618Notes

Reaction equation

HRID 1154618 reaction equation
O.C(O[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([CH:15]=[O:16])=[O:14])CCC.[CH3:17][CH:18]([NH2:30])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=1>CS(C)=O>[CH3:17][CH:18]([N:30]=[C:15]([O:16][CH2:12][CH2:7][CH2:8][CH3:9])[C:13]([C:8]1[CH:7]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:14])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=1

Participants

4

Reactant 2

HCID 8423(+-)-3,4-DimethoxyamphetamineHCID 204341192-n-Butoxyphenylglyoxal hydrate

Product 1

HCID 20434116alpha-(alpha-Methyl-3,4-dimethoxyphenylethylimino)-2-n-butoxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

3.0 g of 2-n-butoxyphenylglyoxal hydrate (crude oil) are dissolved in 9 ml of dimethylsulfoxide, and 2.8 g of α-methyl-3,4-dimethoxyphenethylamine are added thereto. The mixture is stirred at room temperature for 30 minutes, whereby a solution of α-(α-methyl-3,4-dimethoxyphenylethylimino)-2-n-butoxyacetophenone in dimethylsulfoxide is obtained.

Sources & evidence

ORD record
ord-5df15d82b100491892bb4059c52276de
Source dataset
uspto-grants-1984_12
Patent number
US04490392

Reaction notes

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