Triethylamine → n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide

Participants

Reaction Steps

While cooling with ice, a solution of 485.2 gm of 3,4-dimethoxyphenyl-acetic acid chloride in 1.1 liters of methylene chloride at 15° C. to 20° C. was added dropwise to a solution of 246.2 ml of aminoacetaldehyde dimethyl acetal and 315 ml of triethylamine in 2.2 liters of methylene chloride, and the mixture was stirred for one hour at 16° to 18° C. Then, it was extracted with water several times, dried over magnesium sulfate and concentrated by evaporation. The oil thus obtained slowly crystallized.

Provenance & Evidence