7,8-Dimethoxy-3-[3-(methylamino)propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 1-[7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{4-amino-3,5-dibromo-phenyl}-ethyl)-amino]-propane

HRID 1154647Notes

Reaction equation

HRID 1154647 reaction equation
[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[CH2:7][C:8](=[O:17])[N:9]([CH2:12][CH2:13][CH2:14][NH:15][CH3:16])[CH2:10][CH2:11][C:5]=2[CH:4]=1.[NH2:22][C:23]1[C:28]([Br:29])=[CH:27][C:26]([CH2:30][CH2:31]Cl)=[CH:25][C:24]=1[Br:33]>>[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[CH2:7][C:8](=[O:17])[N:9]([CH2:12][CH2:13][CH2:14][N:15]([CH3:16])[CH2:31][CH2:30][C:26]3[CH:27]=[C:28]([Br:29])[C:23]([NH2:22])=[C:24]([Br:33])[CH:25]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 100172197,8-Dimethoxy-3-[3-(methylamino)propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-oneHCID 204338342-(4-Amino-3,5-dibromophenyl)-ethyl chloride

Product 1

HCID 133166791-[7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{4-amino-3,5-dibromo-phenyl}-ethyl)-amino]-propane

Procedure

This compound was prepared analogous to Example 12 from N-[-3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-methylamine and 2-(4-amino-3,5-dibromophenyl)-ethyl chloride.

Sources & evidence

ORD record
ord-b98f969d971946198a02778a97c40a76
Source dataset
uspto-grants-1984_12
Patent number
US04490369

Reaction notes

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