Chloroform → HCID 13316668, compound

Participants

Reaction Steps

3.1 gm (0.007 mol) of 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane were refluxed for 21 hours with 1.0 gm (0.007 mol) of potassium carbonate and 0.6 ml (0.007 mol) of allyl bromide in 100 ml of chloroform. Subsequently, the organic phase was extracted with water, dried, evaporated in vacuo, and the residue was purified on an aluminum oxide column (300 gm neutral, activity III) with methylene chloride containing 2% of acetone as the eluant. Subsequently the hydrochloride was precipitated.

Provenance & Evidence