3-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → HCID 20433761, compound

HRID 1154677Notes

Reaction equation

HRID 1154677 reaction equation
[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14]Cl)[CH2:10][CH2:11][C:5]=2[CH:4]=1.[NH2:21][C:22]1[C:27]([C:28]#[N:29])=[CH:26][C:25]([CH2:30][CH2:31][NH:32][CH3:33])=[CH:24][C:23]=1[Br:34]>>[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14][N:32]([CH3:33])[CH2:31][CH2:30][C:25]3[CH:26]=[C:27]([C:28]#[N:29])[C:22]([NH2:21])=[C:23]([Br:34])[CH:24]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 130925103-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-oneHCID 20433691HCID 20433691, compound

Product 1

HCID 20433761HCID 20433761, compound

Procedure

This compound was prepared analogous to Example 5(b) from 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-chloro-propane and 2-(4-amino-3-bromo-5-cyano-phenyl)-N-methyl-ethylamine.

Sources & evidence

ORD record
ord-03e98af8335c492fa659c3cda0de22ad
Source dataset
uspto-grants-1984_12
Patent number
US04490369

Reaction notes

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