Zatebradine → HCID 13319941, compound

Participants

Reaction Steps

2.28 gm (0.005 mol) of 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane were dissolved in 10 ml of absolute toluene, and the solution was refluxed for 50 minutes with 1.0 gm (0.0025 mol) of 2,4-bis-(4-methoxy-phenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide. After the solvent had been removed in vacuo in a rotary evaporator, the residue was purified on aluminium oxide with methylene chloride plus 2% ethanol as the eluant.

Provenance & Evidence