4-(1-Methylpiperidin-3-ylmethoxy)-phenylamine → HCID 178419039, compound

HRID 11547Notes

Reaction equation

HRID 11547 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:3]1.[F:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](=[CH:28]O)[C:23](=[O:27])[NH:24]2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](=[CH:28][NH:16][C:13]3[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH:4]4[CH2:5][CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]4)=[CH:15][CH:14]=3)[C:23](=[O:27])[NH:24]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 219747984-(1-Methylpiperidin-3-ylmethoxy)-phenylamineHCID 178418700HCID 178418700, compound

Product 1

HCID 178419039HCID 178419039, compoundYield 55%

Procedure

In a manner similar to that described in Example 231, 4-(1-methylpiperidin-3-ylmethoxy)-phenylamine (590 mg, 1.2 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (400 mg, 2.23 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (466 mg, 55%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-d0bf15e3be6f45c0b9d561ea4cb75913
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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