反应详情

A solution of 1.37 g (0.0068 moles) of 3-chlorobenzoisothiazole 1,1-dioxide is added dropwise to 1.7 g (0.0068 moles) of 3-[3-(4-morpholinylmethyl)phenoxy]-1-propanamine in 150 ml of gently refluxing chloroform, over 30 minutes. The reflux is continued for 15 minutes after the end of the addition, then the reaction mixture is evaporated to dryness. The residue is treated with ethanol-ethyl acetate, causing the formation of a yellow-white solid. m.p. 21° C. (dec.) Recrystallization of the crude product from ethanol gave a m.p. of 215° C. (dec.) (1.7 g yield).

1. additionafter the end of the addition
2. customthe reaction mixture is evaporated to dryness
3. additionThe residue is treated with ethanol-ethyl acetate
4. customm.p. 21° C. (dec.) Recrystallization of the crude product from ethanol
5. customgave
6. customa m.p. of 215° C. (dec.) (1.7 g yield)