反应详情

Under a static N2 atm, a stirred solution of the compound of Example 2 (8.14 g, 32 mol) in 100 ml of methanol was treated dropwise with 7.6 g of 25% sodium methoxide in methanol. After stirring at ambient temperature for 24 hr, the mixture was added to H2O and extracted twice with ether. The ether layer was washed with H2O, dried over MgSO4 and concentrated in vacuo to yield a white solid which was recrystallized from methylcyclohexane to yield 5.5 g of methyl 2-methoxy-5-phenyl-4-thiazolecarboxylate as a white solid, m.p. 86°-88° C., yield 70%.

1. extractionextracted twice with ether
2. washThe ether layer was washed with H2O
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo
5. customto yield a white solid which
6. customwas recrystallized from methylcyclohexane