Malonic Acid → HCID 12667864, compound

Participants

Reaction Steps

A 500 ml. three-necked glass flask equipped with a reflux condenser, a thermometer and a stirrer was charged with a mixture consisting of 50 g of 3,5-dimethyl-4-ethoxycarbonyl-phthalic anhydride, 42 g of well-dried malonic acid, 30 g of sodium acetate and 200 g of acetic acid, and the flask was heated in an oil bath. The phthalic anhydride derivative was reacted with malonic acid at 90° to 95° C. for 15 hours with stirring. After the reaction, the reaction mixture was analyzed by high-speed liquid chromatography. It was found that the conversion was 90%, and the desired 5,7-dimethyl-6-ethoxycarbonyl-3-hydroxy-3-methylphthalide was obtained in a yield of 77%.

Provenance & Evidence