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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 11548Generated: October 27, 2026

4-(1-Methylpiperidin-3-ylmethoxy)-phenylamine → HCID 178419003, compound

https://huagongshe.com/reaction/11548

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(1-Methylpiperidin-3-ylmethoxy)-phenylamineHCID 21974798—
Reactant3-(hydroxymethylidene)-1H-indol-2-oneHCID 178418741—
ProductHCID 178419003HCID 17841900381.2%

Reaction Steps

In a manner similar to that described in Example 231, 4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine (656 mg, 1.2 equiv.) and 3-hydroxymethylene-1,3-dihydro-indol-2-one (400 mg, 2.48 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (732 mg, 81%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07098236B2
Source datasetuspto-grants-2006_08
ORD IDord-d3dfcab9abe244c0b588d9f74b10f0ea
Source noteuspto-grants-2006_08