Sodium Hydroxide → HCID 178517459, compound

HRID 1154855Notes

Reaction equation

HRID 1154855 reaction equation
[C:1]([N:9]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)[NH:10][C:11]([NH2:13])=[O:12])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)(=O)C>[C:2]1([C:1]2[N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[N:10]=[C:11]([OH:12])[N:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13091772HCID 13091772, compound

Product 1

HCID 178517459HCID 178517459, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A mixture was prepared by admixing 1.84 g (0.00718 m) of 2-benzoyl-2-(2-pyridinyl)hydrazinecarboxamide with 30 ml of 10 percent sodium hydroxide. The mixture was warmed to 50° C. to dissolve the carboxamide. The solution was held at 50° C. for 10 minutes and the reaction mixture was cooled to room temperature. The reaction product was acidified with 30 ml or 50 percent acetic acid and the white solid which precipitated was recovered by filtration, washed with water and air dried. The 5-phenyl-1-(2-pyridinyl)-1H-1,2,4-triazol-3-ol product was recovered in a yield of 1.12 g (66 percent of theoretical). The product melted at 240°-241° C. and upon analysis was found to have carbon, hydrogen and nitrogen contents of 64.83, 4.35 and 22.46 percent, respectively, as compared with the theoretical contents of 65.53, 4.23 and 23.52.

Workup

  1. customA mixture was prepared
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customthe white solid which precipitated
  4. filtrationwas recovered by filtration
  5. washwashed with water and air
  6. customdried
  7. customThe 5-phenyl-1-(2-pyridinyl)-1H-1,2,4-triazol-3-ol product was recovered in a yield of 1.12 g (66 percent of theoretical)

Sources & evidence

ORD record
ord-0f0a6d85bb964a0db0cbec6924a9f588
Source dataset
uspto-grants-1981_11
Patent number
US04298602

Reaction notes

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