Triethyl phosphite → Diethyl (2,4,6-trimethylbenzoyl)phosphonate

HRID 1154886Notes

Reaction equation

HRID 1154886 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[C:4](Cl)=[O:5].[P:13]([O:20]CC)([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16]>>[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]([P:13](=[O:20])([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16])=[O:5]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 970382,4,6-Trimethylbenzoyl chloride

Product 1

HCID 14930710Diethyl (2,4,6-trimethylbenzoyl)phosphonateYield 36%

Conditions

Temperature
80 °C

Procedure

91 parts of 2,4,6-trimethylbenzoyl chloride are introduced into an apparatus as described in Example 1. 83 parts of triethyl phosphite are added in the course of 15 minutes at 60° C., after which the mixture is stirred for 8 hours at 80° C. The material discharged from the flask is distilled under a pressure of 0.4 mm and the fraction boiling at 120°-122° C. under this pressure is collected. 51 parts (36 percent of theory) of diethyl 2,4,6-trimethylbenzoylphosphonate are obtained as a pale yellowish liquid.

Workup

  1. distillationis distilled under a pressure of 0.4 mm
  2. customthe fraction boiling at 120°-122° C. under this pressure is collected

Sources & evidence

ORD record
ord-da006672f84140d0972deca8db5f1a2c
Source dataset
uspto-grants-1981_11
Patent number
US04298738

Reaction notes

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