HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3-Azido-4-(2-trifluoroacetoxyethyl)azetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 3-Azido-4-(2-hydroxyethyl)-2-azetidinone | HCID 15592389 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Azido-4-(2-trifluoroacetoxyethyl)azetidin-2-one | HCID 54331764 | — |
Reaction Steps
Trifluoroacetic anhydride (0.2 mol) is added dropwise to an ice-cold, stirred solution of 3-azido-4-(2-hydroxyethyl)-azetidin-2-one (0.2 mol) and pyridine (0.21 mol) in methylene chloride (200 ml). The solution is stirred for 15 more min. at room temperature (25° C.), then washed with water, dried with magnesium sulfate, and filtered. Evaporation of the methylene chloride under vacuum leaves 3-azido-4-(2-trifluoroacetoxyethyl)azetidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04298741 |
| Source dataset | uspto-grants-1981_11 |
| ORD ID | ord-3993c06d10d34cd0bcb9ce30aae4000f |
| Source note | uspto-grants-1981_11 |