HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → Cilostamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,6-Dihydroxyquinoline | HCID 177065 | — |
| Reactant | 4-Chloro-N-cyclohexyl-N-methylbutanamide | HCID 13208297 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Cilostamide | HCID 2753 | — |
Reaction Steps
1.6 Grams of 6-hydroxycarbostyril, 1.4 g of K2CO3, 1.6 g of sodium iodide and 2.5 g of N-methyl-N-(4-chlorobutyryl)cyclohexylamine are added to 30 ml of DMF and the mixture is agitated at 70° to 80° C. for 4 hours. After the reaction, the reaction solution is poured into 200 ml of saturated NaCl solution and the precipitated crystals are filtered out and washed with water. The resultant crude crystals are recrystallized from chloroformethanol to obtain 1.5 g of 6-[3-(N-methyl-N-cyclohexylaminocarbonyl)propoxy]carbostyril in the form of colorless needle-like crystals with melting point of 184.5°-186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04298739 |
| Source dataset | uspto-grants-1981_11 |
| ORD ID | ord-d81d36cf128a44aa9cb243a2f1979625 |
| Source note | uspto-grants-1981_11 |