反应详情

To a solution of 2.8 g of 1-methyl-6-[3-(N-methyl-N-cyclohexylaminocarbonyl)propoxy]carbostyril in 50 ml of methanol is added 0.1 g of palladium black, and the mixture is reacted at 50° C. under hydrogen pressure of 2.5 atm. for 8 hours. After the reaction, the catalyst is filtered out and the filtrate is concentrated and evaporated to dryness. The residue is recrystallized from ligroin to obtain 1.9 g of 1-methyl-6-[3-(N-methyl-N-cyclohexylaminocarbonyl)propoxy]-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with melting point of 104.5°-106.5° C.

1. customthe mixture is reacted at 50° C. under hydrogen pressure of 2.5 atm. for 8 hours
2. customAfter the reaction
3. filtrationthe catalyst is filtered out
4. concentrationthe filtrate is concentrated
5. customevaporated to dryness
6. customThe residue is recrystallized from ligroin