3-(Trifluoromethyl)phenylhydrazine Hydrochloride → HCID 1486556, compound

HRID 1154986Notes

Reaction equation

HRID 1154986 reaction equation
Cl[C:2]1[CH:3]=[C:4]([N:8]2[C:12](=[O:13])[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=3)=[CH:10][N:9]2CC)[CH:5]=[CH:6][CH:7]=1.Cl.[F:24][C:25]([F:35])([F:34])C1C=C(NN)C=CC=1>CO>[Cl:20][C:16]1[CH:15]=[C:14]([C:11]2[C:12](=[O:13])[N:8]([C:4]3[CH:3]=[C:2]([C:25]([F:35])([F:34])[F:24])[CH:7]=[CH:6][CH:5]=3)[NH:9][CH:10]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 27333103-(Trifluoromethyl)phenylhydrazine HydrochlorideHCID 12813188HCID 12813188, compound

Product 1

HCID 1486556HCID 1486556, compoundYield 37.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 12 grams of the 3-chloroatropic acid, methyl ester (prepared in Example 9 above), 13 grams 3-(trifluoromethyl)phenylhydrazine hydrochloride and 100 ml. methanol was refluxed overnight to yield 4.6 grams of 4-(3-chlorophenyl)-1-(α,α,α-trifluoro-3-tolyl)-3-pyrazolin-5-one, m.p. 190°-192° C.

Sources & evidence

ORD record
ord-7f8ef365848d4edea7c58686ad42ff18
Source dataset
uspto-grants-1981_11
Patent number
US04299614

Reaction notes

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