HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(1-Methyl-2-pyrrolylcarbonyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | 1-Methyl-1H-pyrrole-2-carbaldehyde | HCID 14504 | — |
| Reactant | (1-methyl-1H-pyrrol-2-yl)(morpholin-4-yl)acetonitrile | HCID 20529962 | — |
| Product | 3-(1-Methyl-2-pyrrolylcarbonyl)propionic acid | HCID 12504054 | — |
Reaction Steps
As for Example 6, 1-methyl-2-pyrrolecarboxaldehyde is converted to α-(1-methyl-2-pyrrolyl)-4-morpholineacetonitrile. The preceding compound is reacted with ethyl acrylate and the resulting 1,4-addition product is heated at 100° C. with 6 N hydrochloric acid to give 3-(1-methyl-2-pyrrolylcarbonyl)propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04299769 |
| Source dataset | uspto-grants-1981_11 |
| ORD ID | ord-4913ddbca2124d7e89083018fe061be3 |
| Source note | uspto-grants-1981_11 |