Phosphorus pentachloride → 61984-67-6

HRID 1155047Notes

Reaction equation

P(Cl)(Cl)(Cl)(Cl)[Cl:2].[F:7][C:8]([F:23])([F:22])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]([F:21])([F:20])[F:19])=O>>[F:7][C:8]([F:23])([F:22])[C:9]([Cl:2])=[N:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]([F:21])([F:20])[F:19]

Participants

Reactant 2

HCID 24819Phosphorus pentachloride

HCID 200624Acetanilide, 2,2,2-trifluoro-2'-(trifluoromethyl)-

Product 1

HCID 1247173661984-67-6Yield 46%

Conditions

Temperature: 80 °C

Procedure

A mixture of 27.48 g of phosphorus pentachloride and 30.84 g of 2,2,2-trifluoro-N-(2-trifluoromethylphenyl)-acetamide was stirred at 80° C. for 4 hours and was then allowed to cool. The mixture was distilled under reduced pressure to obtain 15.2 g of 2,2,2-trifluoro-N-(2-trifluoromethylphenyl)ethanimidoyl chloride with a boiling point of 85° C. at 30 mm Hg and a refractive index of nD21 =1.4297.

Workup

temperatureto cool
distillationThe mixture was distilled under reduced pressure

Sources & evidence

ORD record: ord-438af0ad68d747839e8aeaf3ca538298
Source dataset: uspto-grants-1981_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04299831

Reaction notes

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