Thionyl Chloride → HCID 178521117, compound

HRID 1155049Notes

Reaction equation

HRID 1155049 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]([F:26])([F:25])[C:7]1[C:16]([C:17](O)=[O:18])=[C:15]([OH:20])[C:14]2[C:9](=[C:10]([C:21]([F:24])([F:23])[F:22])[CH:11]=[CH:12][CH:13]=2)[N:8]=1>C1C=CC=CC=1>[F:5][C:6]([F:26])([F:25])[C:7]1[C:16]([C:17]([Cl:3])=[O:18])=[C:15]([OH:20])[C:14]2[C:9](=[C:10]([C:21]([F:24])([F:23])[F:22])[CH:11]=[CH:12][CH:13]=2)[N:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178524538HCID 178524538, compound

Product 1

HCID 178521117HCID 178521117, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

9.6 ml of thionyl chloride were added with stirring to a suspension of 8.75 g of the product of Step D in 285 ml of benzene and the mixture was refluxed for 90 minutes. Then, the benzene and excess thionyl chloride was evaporated and the residue was taken up twice in anhydrous benzene to obtain 2,8-bis-(trifluoromethyl)-4-hydroxy-3-quinoline-carboxylic acid chloride which was used as is for the next step.

Workup

  1. temperaturethe mixture was refluxed for 90 minutes
  2. customThen, the benzene and excess thionyl chloride was evaporated

Sources & evidence

ORD record
ord-bdd2dba9a4034d42b7eca19818958c64
Source dataset
uspto-grants-1981_11
Patent number
US04299831

Reaction notes

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