反应详情

9.6 ml of thionyl chloride were added with stirring to a suspension of 8.75 g of the product of Step D in 285 ml of benzene and the mixture was refluxed for 90 minutes. Then, the benzene and excess thionyl chloride was evaporated and the residue was taken up twice in anhydrous benzene to obtain 2,8-bis-(trifluoromethyl)-4-hydroxy-3-quinoline-carboxylic acid chloride which was used as is for the next step.

1. temperaturethe mixture was refluxed for 90 minutes
2. customThen, the benzene and excess thionyl chloride was evaporated